李瀛

个人简介

1993年在兰州大学获得有机化学专业有机合成方向博士学位（导师：李裕林教授）。李瀛教授长期从事有机化学的教学和科研工作，已合作出版《有机化学》、《有机化学实验》、《有机化学质疑暨考研指导》、《有机化学简明教程》教材四部。主讲的“有机化学”课程获2005年度甘肃省精品课程，2009年度甘肃省高等教育教学成果二等奖。李瀛教授的研究领域为具有生物活性的复杂天然产物的全合成以及新药合成路线和药物中间体的研制与开发。曾主持和完成国家自然科学基金项目五项；国家重点实验室基金和省自然科学基金课题及企业合作多项。李瀛教授已在J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,Org. Lett., Synlett 等国内外高水平杂志上合作发表研究论文150余篇。

研究方向

● 具有重要生物活性天然产物的全合成；

● 构筑螺环缩酮及虎皮楠生物碱骨架的方法学研究；

● 基于新药开发为导向的有机合成基础与应用研究。

荣获奖项

国家科技进步二等奖一项（2009）；

教育部科技进步一等奖一项（2008），二等奖二项（1994，2001）；

广西壮族自治区科技进步三等奖一项（2004）；

1997年荣获宝钢教育奖学金优秀教师奖；

2005年享受国务院政府特殊津贴。

发表论文

1. Wenjing Wang, Jijun Xue, Tian Tian, Jie Zhang, Liping Wei, Jidong Shao, Zhixiang Xie, and

Ying Li*

. Total Synthesis of (±)-δ-Rubromycin.Org. Lett.,

2013

,15, 2402–2405.

2. Wanchun Gong, Yun Liu, Jie Zhang, Yingdong Jiao, Jijun Xue,* and

Ying Li*

. Regio- and Stereoselective [4+3] Cycloaddition Towards Fused 5,7,6-Tricyclic Skeletons.Chem. Asian J.,

2013

,8, 546–551.

3. Jie Zhang, Liqi Li, Yongxiang Wang, Wenjing Wang, Jijun Xue* and

Ying Li*

. A Novel, Facile Approach to Frondosin B and 5-epi-Liphagalvia a New [4 + 3] Cycloaddition.Org. Lett.,

2012

，14, 4528–4530.

4. Bo Zhang, Yao Wang, Sheng-Ping Yang, Yu Zhou, Wen-Bin Wu, Wei Tang, Jian-Ping Zuo,

Ying Li*.

and Jian-Min Yue*. Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucidation and Bioinspired Total Synthesis.J. Am. Chem. Soc.,

2012

,134, 20605–20608.

5. Wei Wei, Yao Wang, Jianpeng Yin, Jijun Xue,* and

Ying Li*

. Construction of Aromatic [5,5] Spiroketals via Hypoiodite-Catalyzed Etherification Combined in Relay Cascades.Org. Lett.,

2012

,14, 1158–1161.

6. Xin Li, Jijun Xue, Chusheng Huang, and

Ying Li*

. Copper(I)-Catalyzed Hydroalkoxylation/Hydrogen-Bonding-Induced Asymmetric Hetero- Diels–Alder Cycloaddition Cascade: An Approach to Aromatic Spiroketals.Chem. Asian J.,

2012

,7, 903–906.

7. Wei Wei, Liqi Li, Xiaohong Lin, Haifeng Li, Jijun Xue* and

Ying Li*

. New fluoride-promoted hypoiodite-catalytic oxidative cycloetherification to aromatic spiroketals.Org. Biomol. Chem.,

2012

,10, 3494–3499.

8. Xin Li, Jijun Xue*, Rui Chen,

Ying Li*

. A New Copper(I)-Catalyzed Cycloetherification/Acid-Catalyzed Allylic Nucleophilic Substitution for One-Pot Synthesis of 2-Substituted Benzofurans.Synlett,

2012

,23, 1043–1046.

9. Xiaolong Zhao, Jie Liu, Zhixiang Xie*,

Ying Li*

. A One-Pot Synthesis of Aurones from Substituted Acetophenones and Benzaldehydes: A Concise Synthesis of Aureusidin.Synthesis,

2012

,44, 2217–2224.

10. Liping Wei, Jijun Xue,* Hongbiao Liu, Wenjing Wang, and

Ying Li*

. Synthesis of γ-Rubromycin via a New Hypoiodite-Catalytic Oxidative Cycloetherification.Org. Lett.,

2012

,14, 5302–5305.

11. Zhijun Xin, Yuan Zhang, Hua Tao, Jijun Xue*,

Ying Li*

. Dramatic Base-Oriented Chemoselective Tandem Wacker Cyclizations: Synthesis of Bisbenzannelated Spiroketals and 2-Substituted Chromans.Synlett,

2011

,7, 1579–1584.

12. Deping Zheng, Wanchun Gong, Zuodong Ma, Bingzhen Ma, Xiaolong Zhao, Zhixiang Xie*,

Ying Li*

. Unexpected Prins cyclization: iron-promoted cyclization/hydrationof alkynyl-dimethyl acetals.Tetrahedron Letters,

2011

,52, 314–317.

13. Deping Zheng, Zuodong Ma, Wanchun Gong, Zhixiang Xie*.

Ying Li*

, FeCl Promoted One-step Synthesis of Spiro[4,5]decane Derivatives.Synlett,

2010

,14, 2169–2173.

14. Chao Du, Liqi Li,

Ying Li

, Zhixiang Xie*. Construction of Two Vicinal Quaternary Carbons by Asymmetric Allylic Alkylation: Total Synthesis of Hyperolactone C and (-)-Biyouyanagin A.Angew. Chem. Int. Ed.;

2009

,48, 7853–7856.

15. Yuan Zhang, Jijun Xue, Zhijun Xin, Zhixiang Xie,

Ying Li*

. Gold-Catalyzed Double Intramolecular Alkyne Hydroalkoxylation: Synthesis of the Bisbenzannelated Spiroketal Core of Rubromycins Synthesis of the Biusbenzannelaated Spirokental Core of Rubromycins.Synlett,

2008

, (6), 940–944.

16. Degang Liu, Jijun Xue, Zhixiang Xie, Liping Wei, Xianshu Zhang,

Ying Li*

. Formal Total Synthesis of Benzylpedamide: The Right Half of (+)-Pederin.Synlett,

2008

,10, 1526–1528.

17. Guanglian Zhou, Jianrong Zhu, Zhixiang Xie,* and

Ying Li*.

An Efficient Synthesis of Highly Functionalized [5,6] Aromatic Spiroketals by Hetero-Diels-Alder Reaction.Org. Lett.,

2008

,10(5), 721–724.